Mill Spring, MO

Mill Spring is a tiny Missouri Ozarks community in Wayne County, reachable via Highway 34 from Cape Girardeau (45 miles southeast) or through Highway 21 from the north. Long-distance visitors typically drive from St. Louis using Interstate 55 south, then state highways for the final approach. The town sits along Greenville Creek, named for the historic gristmill that once operated on its banks.