Saltillo, MS

Saltillo lies 15 miles southeast of Tupelo along US Highway 45, Mississippi's main north-south corridor through the region. State Route 6 provides east-west connections, while longer-distance travelers typically reach the area via US-78 or Interstate 22 through Tupelo. The town of 5,000 sits in rolling hill country with a humid subtropical climate. The 1906 Lee County Courthouse anchors the historic downtown square.