How far is it from Louisville, TN to Knoxville, TN?

The distance between Louisville, TN and Knoxville, TN is 21 mi by road.

How long does it take to drive from Louisville, TN to Knoxville, TN?

The drive from Louisville, TN to Knoxville, TN takes approximately 40 min by car.

The fastest route from Louisville, TN to Knoxville, TN covers 21 mi with a driving time of approximately 40 min.

Knoxville, TN lies roughly to the north-east of Louisville, TN.

Distance: 21 miDuration: 40 min

Driving from Louisville, TN to Knoxville, TN takes about 40 min via US 129. The distance is 21 mi. The straight-line distance is 12 mi. Driving directions

Driving directions23 · 21 mi

The return trip from Knoxville, TN to Louisville, TN covers roughly the same distance, 21 mi.

No notable attractions were found along this route.

Distance and drive time are computed from OpenStreetMap road data with the OSRM routing engine. Updated 7 October 2026.

How far is it from Louisville, TN to Knoxville, TN?: The distance between Louisville, TN and Knoxville, TN is 21 mi by road.
How long does it take to drive from Louisville, TN to Knoxville, TN?: The drive from Louisville, TN to Knoxville, TN takes approximately 40 min by car.
What is the best route from Louisville, TN to Knoxville, TN?: The fastest route from Louisville, TN to Knoxville, TN covers 21 mi with a driving time of approximately 40 min.
Which direction is Knoxville, TN from Louisville, TN?: Knoxville, TN lies roughly to the north-east of Louisville, TN.